Hello, Jkjones,
I am glad that your first instinct is to diagram these questions!

For Assumption questions, though, another type of diagram may be more effective. This is what I teach in the Weekend and Full-Length Courses I've done in the past.
An assumption is simply an unstated premise. Therefore, an Assumption question will contain some amount of premises and a conclusion in its stimulus, and the correct answer choice will contain the unstated premise that completes the argument. For this question, think of it like this:
P1: No MP can be PTBO
P2: ???
C: No MP can be known to be true
P2 is our missing premise, which must therefore be the correct answer choice.

In this case, you're trying to link together "can be PTBO" with "can be known to be true". Looking at answer choice E lets us bring in the following to the diagram:
P1: No MP can be PTBO
P2: No thing that is not PTBO can be known to be true
C: No MP can be known to be true
That is a rephrasing of answer choice E, but it fits the diagram a little better. Often tricky phrasing will be the major source of difficulty in questions like these - learning to restate sentences in more clear language is a super useful skill!
As you can see, the argument is now logically sound. If no MP can be PTBO, and something must be PTBO to be able to be known to be true, then no MP can be known to be true. None of the other answer choices complete the argument so neatly.
Almost all Assumption questions can be answered this way. Practice if you like!
Hope that helps,
Lucas Moreau